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Pantoka 40

Acid Peptic Disorders

APDs include a spectrum of disorders resulting from damaging action of Acid ( HCL) & Pepsin

Peptic ulcer

  • A peptic ulcer is a sore on the lining of stomach or duodenum

Gastric ulcer : Ulcer found in stomach

Duodenal ulcer : Ulcer in duodenum

Treatment goals :

  • A peptic ulcer is a sore on the lining of stomach or duodenum
  • To relieve  symptom - pain
  • To promote  ulcer  healing
  • To prevent  complications
  •  To prevent  recurrence  of ulcers

PPIs drugs of choice

GERD

  • One of the most common disorders of upper GI tract
  • GERD develops when the oesophagus is inflamed by exposure to refluxed acidic content from the stomach ( Acid & Pepsin)

GERD : Symptoms

  • Symptoms:
    • Heartburn
    • Acid regurgitation
    • Hypersalivation

Pantoka 40

  • Pantoprazole Blocks proton pump (H+/K+-ATPase) of parietal cells of  stomach- the final step of acid production
  • Quick Onset of action: 1-3 hours
  • Profound & long-lasting suppression of HCL secretion- Upto 24 hours

Pantoprazole: Indications

  • Symptomatic  treatment   of  GERD
  • Healing  of  erosive  or  ulcerative  GERD
  • Maintenance  therapy : To prevent  relapse  of  GERD
  • Healing  of  active  duodenal  ulcers
  • Healing  of  benign  gastric  ulcers

Co-administration with gastric irritant drugs like NSAIDs/ Aspirin/Steroids for-

  • Prevention of drug induced ulcers
  • Treatment of drug induced ulcers

Pantoprazole: Dosage & Administration

Adult:

Treatment: 40 mg OD for 4 to 8 weeks

Maintenance: 20 mg OD

Administration: Pantoprazole should be taken once daily, before breakfast or meal

Pantoka-D

Each Capsule contains:

  • Pantoprazole EC granules 0 mg
  • Domperidone SR 30 mg

Domperidone

  • Most widely prescribed D2 receptor antagonist

Dual actions:

  • Anti-emetic: Relieves nausea & vomiting
  • Prokinetic: Promotes peristalsis of upper GI tract

No effect on acid secretion

Pantoka-D

Indications:

  • Moderate to severe cases of GERD- Not responding to Pantoprazole monotherapy
  • Functional dyspepsia with nausea, vomiting
  • Peptic ulcer with nausea, vomiting
  • Drug-induced gastritis

Dosage and Administration

Adults:

  • capsule to be taken orally once daily, 1 hour before breakfast

Duration - depends on the disease condition

Swallow the capsule whole
Do not chew, crush, or split